Data de entrada: 14 de mai. de 2022


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Category: Tamil language Category: Tamil cinemaModulatory effects of zibotentan on the proliferation and tumorigenicity of mouse and human mesothelioma cells. Because of the limited clinical efficacy of current treatment options for malignant mesothelioma, it is imperative to develop novel therapeutic strategies for this disease. We have previously shown that the Mas-related G protein-coupled receptor kinase (MrgX2) is overexpressed in malignant mesothelioma and that selective MrgX2 receptor (MRGX2) antagonists inhibit the proliferation of cultured human mesothelioma cells. Herein, we have assessed the in vitro antitumor efficacy of zibotentan, a MrgX2-selective antagonist, in two different mesothelioma cell lines, namely the human mesothelioma cell line A431 and the murine mesothelioma cell line Ab1. We also evaluated the antitumor efficacy of zibotentan in vivo in a murine model of human malignant mesothelioma using A431 cells injected into the pleural space of BALB/c nude mice. We found that zibotentan induced apoptosis in A431 cells in a dose-dependent manner and suppressed cell proliferation in both human and murine mesothelioma cells. In vivo, zibotentan effectively inhibited the tumorigenicity of A431 cells in BALB/c nude mice. The results of our study demonstrate that zibotentan inhibits the proliferation of human and mouse mesothelioma cells in vitro and in vivo. Furthermore, our results show that zibotentan possesses antitumor activity in a murine model of human mesothelioma and suggest that this compound may have potential therapeutic utility in malignant mesothelioma.Mn-doped hydroxyapatite nanoparticles synthesized by microwave-assisted electrodeposition. A microwave-assisted electrodeposition method was developed to synthesize Mn-doped hydroxyapatite nanoparticles. The effect of Mn doping on the structural and luminescence properties of the as-synthesized hydroxyapatite nanoparticles was investigated. The X-ray diffraction patterns indicated that the hydroxyapatite nanoparticles were pure and without any impurities. The morphology of the Mn-doped hydroxyapatite nanoparticles was characterized using scanning electron microscopy.




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